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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 379 - 385 (7page)
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초록· 키워드
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The extraction and solvent partition of cornstalks, and repeated column chromatography for EtOAc fraction yielded four phenolic compounds, methyl (Z)-p-coumarate (1), methyl (E)-p-coumarate (2), methyl ferulate (3), and 1,3-O-diferuloyl glycerol (4). The chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, and IR. All compounds were isolated for the first time from the cornstalks. Compounds 1, 2, and 4 were evaluated for inhibition activity on NO production in lipopolysaccharide-induced RAW 264.7 cells, neuroprotective activity on glutamate-induced cell death in HT22 cells, and hepatoprotective activity on t-BHP-induced oxidative stress in HepG2 cells. Compounds 2 and 4 showed inhibitory effects on NO production with the $IC_{50}$ values of 19.29 and $5.62{\mu}M$, respectively, and compound 4 showed protective effect on glutamate-induced cell death and t-BHP-induced oxidative stress with $EC_{50}$ values of 19.51 and $71.29{\mu}M$, respectively.
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