지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 104 - 112 (9page)
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The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-${\alpha}$, IL-6, and IL-$1{\beta}$ were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheumatoid arthritis.
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참고문헌 (35)
참고문헌 신청
Ahmad, I. / 1998 / Screening of some Indian medicinal plants for their antimicrobial properties / J. Ethnopharmacol 62:183~193
안미정 / 200201 / Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis / Planta Medica 68(5):457~459
Badmaev, V. / 2000 / Protection of epithelial cells against infl uenza A virus by a plant derived biological response modifi er Ledretan-96 / Phytother. Res 14:245~249
Bhattacharya, S. / 2007 / Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats / J. Clin. Biochem. Nutr 41:106~114
Ehrenstein, M. R. / 2004 / Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy / J. Exp. Med 200:277~285
안미정 / 200201 / Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis / Planta Medica 68(5):457~459
Badmaev, V. / 2000 / Protection of epithelial cells against infl uenza A virus by a plant derived biological response modifi er Ledretan-96 / Phytother. Res 14:245~249
Bhattacharya, S. / 2007 / Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats / J. Clin. Biochem. Nutr 41:106~114
Ehrenstein, M. R. / 2004 / Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy / J. Exp. Med 200:277~285
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