지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 328 - 335 (8page)
이용수
초록· 키워드
오류제보하기
This study was undertaken to investigate whether honokiol could enhance the pentobarbitalinduced sleeping behaviors through $\gamma$-aminobutyric acid (GABA) receptor $Cl^-$ channel activation. Thirty minutes after the oral administration of honokiol, mice were received sodium pentobarbital (42 mg/kg, i.p.). The time elapsed from pentobarbital injection to the loss of the righting reflex was taken as sleeping latency. The time elapsed between the loss and voluntary recovery of the righting reflex was considered as the total sleeping time. Western blot technique and $Cl^-$ sensitive fluorescence probe were used to detect the expression of $GABA_A$ receptor subunits and $Cl^-$ influx in the primary cultured cerebellar granule cells. Honokiol (0.1 and 0.2 mg/kg) prolonged the sleeping time induced by pentobarbital (42 mg/kg) in a dosage-dependent manner. Honokiol (20 and 50 ${\mu}M$) increased $Cl^-$ influx in primary cultured cerebellar granule cells, and selectively increased the $GABA_A$ receptor $\alpha$-subunit expression, but had no effect on the abundance of $\beta$ or $\gamma$-subunits. Chronic treatment with 20 ${\mu}M$ honokiol in primary cultured cerebellar neurons did not affect the abundance of GAD65/67. The results suggested that honokiol could potentiate pentobarbital-induced sleeping through $GABA_A$ receptor $Cl^-$ channel activation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
GABA 수용체 영상
핵의학분자영상
2007 .01
-
Effects of Ginsenosides on GABA_A_ and GABA_B_ Receptors
International Symposium on Ginseng
1990 .07
-
Administration of Alpha<sub>s1</sub>-Casein Hydrolysate Increases Sleep and Modulates GABA<sub>A</sub> Receptor Subunit Expression
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
인삼사포닌이 GABA A 및 B수용체에 미치는 영향 ( Effects of Ginsenosides on GABA_A_ and GABA_B_ Receptors )
Journal of Ginseng Research
1990 .12
-
Tranquilizer-like Effects of Sanjoinine A: Possible GABA/Benzodiazepine Receptors Complex Involvement
한국응용약물학회 춘계학술발표논문집
2008 .01
-
복합한약제제의 수면에 대한 연구 : 더웰 제제에 대하여
동의생리병리학회지
2011 .12
-
개의 기관근 수축성에 미치는 GABA의 효과
영남의대학술지
1994 .01
-
흰쥐의 뮤시몰투여에 의한 배뇨반사억제효과에 대한 벤조디아제핀수용체의 영향
약학회지
1992 .01
-
흰쥐 적출 소장의 수축성에 미치는 GABA의 영향
영남의대학술지
1991 .01
-
Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABA-ergic Systems in Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
복합한약제제가 Pentobarbital에 의해 유도된 수면시간에 미치는 영향
동의생리병리학회지
2013 .12
-
Electrophysiological evaluation of GABA synaptic plasticity using brain slice patch camp technique
한국실험동물학회 학술발표대회 논문집
2012 .08
-
Effects of GABA Receptor Antagonist on the Cardiovascular Response of Adenosine A and Adenosine A Receptor Agonist in the Spinal Cord of the Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
-
흰쥐의 적출 정관 수축성에 대한 ${\gamma}$-Aminobutyric Acid의 억제작용
영남의대학술지
1992 .01
-
카페인 투여 흰쥐의 뇌 부위별 GABA 함량 변화
스트레스硏究
2010 .06
-
Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the $GABA_A$ receptor
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
Electrically Stimulated Relaxation is not Mediated by GABA in Cat Lower Esophageal Sphincter Muscle
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0