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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 288 - 294 (7page)
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초록· 키워드
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Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-inflammatory effect and underlying molecular mechanisms of MF in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. MF dose-dependently inhibited the production of NO, iNOS, and pro-inflammatory cytokines (TNF-${\alpha}$, IL-6, and IL-$1{\beta}$) in LPS-stimulated RAW264.7 macrophages. Moreover, MF decreased the NF-${\kappa}B$ luciferase activity and NF-${\kappa}B$ DNA binding capacity in LPS-stimulated RAW264.7 macrophages. Furthermore, MF suppressed the NF-${\kappa}B$ activation by inhibiting the degradation of $I{\kappa}B{\alpha}$ and nuclear translocation of p65 subunit of NF-${\kappa}B$. In addition, MF attenuated the AP-1 luciferase activity and phosphorylation of ERK, JNK, and p38 MAP kinases. Taken together, these results suggest that the anti-inflammatory effect of MF is associated with the suppression of NO production and iNOS expression through the down-regulation of NF-${\kappa}B$ activation and MAPK signaling pathway in LPS-stimulated RAW264.7 macrophages.
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참고문헌 (23)
참고문헌 신청
Choi, W. S / 2012 / The regulatoryeffect of veratric acid on NO production in LPS-stimulatedRAW264.7 macrophage cells / Cell. Immunol 280:164~170
Ci, X / 2010 / Schisantherin A exhibits anti-infl ammatory propertiesby down-regulating NF-κB and MAPK signaling pathwaysin lipopolysaccharide-treated RAW 264.7 cells / Infl ammation 33:126~136
Fengyang, L / 2012 / Stevioside suppressed infl ammatory cytokine secretion bydownregulation of NF-κB and MAPK signaling pathways in LPSstimulatedRAW264.7 cells / Infl ammation 35:1669~1675
Gao, Y / 2012 / Anti-infl ammatory effects of sophocarpine inLPS-induced RAW 264.7 cells via NF-κB and MAPKs signalingpathways / Toxicol. In Vitro 26:1~6
Han, J. M / 2010 / Lavandulyl fl avonoids from Sophora fl avescens suppresslipopolysaccharide-induced activation of nuclear factor-κB and mitogen-activated protein kinases in RAW264.7 cells / Biol. Pharm.Bull 33:1019~1023
Ci, X / 2010 / Schisantherin A exhibits anti-infl ammatory propertiesby down-regulating NF-κB and MAPK signaling pathwaysin lipopolysaccharide-treated RAW 264.7 cells / Infl ammation 33:126~136
Fengyang, L / 2012 / Stevioside suppressed infl ammatory cytokine secretion bydownregulation of NF-κB and MAPK signaling pathways in LPSstimulatedRAW264.7 cells / Infl ammation 35:1669~1675
Gao, Y / 2012 / Anti-infl ammatory effects of sophocarpine inLPS-induced RAW 264.7 cells via NF-κB and MAPKs signalingpathways / Toxicol. In Vitro 26:1~6
Han, J. M / 2010 / Lavandulyl fl avonoids from Sophora fl avescens suppresslipopolysaccharide-induced activation of nuclear factor-κB and mitogen-activated protein kinases in RAW264.7 cells / Biol. Pharm.Bull 33:1019~1023
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