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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 232 - 238 (7page)
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Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Ab). Specific mechanisms underlying the development of the disease have not yet been fully understood. In this study, we investigated effects of 4-O-methylhonokiol on memory dysfunction in APP/PS1 double transgenic mice. 4-O-methylhonokiol (1 mg/kg for 3 month) significantly reduced deficit in learning and memory of the transgenic mice, as determined by the Morris water maze test and step-through passive avoidance test. Our biochemical analysis suggested that 4-O-methylhonokiol ameliorated $A{\beta}$ accumulation in the cortex and hippocampus via reduction in beta-site APP-cleaving enzyme 1 expression. In addition, 4-O-methylhonokiol attenuated lipid peroxidation and elevated glutathione peroxidase activity in the double transgenic mice brains. Thus, suppressive effects of 4-O-methylhonokiol on $A{\beta}$ generation and oxidative stress in the brains of transgenic mice may be responsible for the enhancement in cognitive function. These results suggest that the natural compound has potential to intervene memory deficit and progressive neurodegeneration in AD patients.
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참고문헌 (34)
참고문헌 신청
Ai, J / 2013 / MicroRNA-195 protects against dementia induced by chronic brainhypoperfusion via its anti-amyloidogenic effect in rats / J. Neurosci 33:3989~4001
Ashton, J. C / 2007 / The cannabinoid CB2 receptoras a target for inflammation-dependent neurodegeneration / Curr.Neuropharmacol 5:73~80
Borchelt, D. R / 1997 / Accelerated amyloid deposition in the brains of transgenicmice coexpressing mutant presenilin 1 and amyloid precursor proteins / Neuron 19:939~945
Bourne, K. Z / 2007 / Differential regulation of BACE1promoter activity by nuclear factor-kappaB in neurons and gliaupon exposure to beta-amyloid peptides / J. Neurosci. Res 85:1194~1204
Chen, C. H / 2012 / Increased NF-kappaB signallingup-regulates BACE1 expressionand its therapeutic potential in Alzheimer'sdisease / Int. J. Neuropsychopharmacol 15:77~90
Ashton, J. C / 2007 / The cannabinoid CB2 receptoras a target for inflammation-dependent neurodegeneration / Curr.Neuropharmacol 5:73~80
Borchelt, D. R / 1997 / Accelerated amyloid deposition in the brains of transgenicmice coexpressing mutant presenilin 1 and amyloid precursor proteins / Neuron 19:939~945
Bourne, K. Z / 2007 / Differential regulation of BACE1promoter activity by nuclear factor-kappaB in neurons and gliaupon exposure to beta-amyloid peptides / J. Neurosci. Res 85:1194~1204
Chen, C. H / 2012 / Increased NF-kappaB signallingup-regulates BACE1 expressionand its therapeutic potential in Alzheimer'sdisease / Int. J. Neuropsychopharmacol 15:77~90
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