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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 35 - 40 (6page)
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초록· 키워드
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Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits ${\alpha}$-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.
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참고문헌 (21)
참고문헌 신청
Baur, J. A / 2006 / Therapeutic potential of resveratrol:the in vivo evidence / Nat. Rev. Drug Discov 5:493~506
Bertolotto, C / 1998 / Different cis-acting elements are involvedin the regulation of TRP1 and TRP2 promoter activities by cyclicAMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia / Mol. Cell. Biol 18:694~702
Chen, Y. J / 2013 / Resveratrol Inhibits alpha-melanocyte-stimulating hormone signaling,viability, and invasiveness in melanoma cells / Evid. Based Complement.Alternat. Med 2013:632121
Del Follo-Martinez A / 2013 / Resveratrol and quercetin in combination have anticanceractivity in colon cancer cells and repress oncogenic microRNA-27a / Nutr. Cancer 65:494~504
Franco, D. C / 2012 / Inhibitory effects of resveratrolanalogs on mushroom tyrosinase activity / Molecules 17:11816~11825
Bertolotto, C / 1998 / Different cis-acting elements are involvedin the regulation of TRP1 and TRP2 promoter activities by cyclicAMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia / Mol. Cell. Biol 18:694~702
Chen, Y. J / 2013 / Resveratrol Inhibits alpha-melanocyte-stimulating hormone signaling,viability, and invasiveness in melanoma cells / Evid. Based Complement.Alternat. Med 2013:632121
Del Follo-Martinez A / 2013 / Resveratrol and quercetin in combination have anticanceractivity in colon cancer cells and repress oncogenic microRNA-27a / Nutr. Cancer 65:494~504
Franco, D. C / 2012 / Inhibitory effects of resveratrolanalogs on mushroom tyrosinase activity / Molecules 17:11816~11825
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