Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells

Kim, Hye Young; Park, Min; Kim, Kyong; Lee, Yu Mi; Rhyu, Mee Ra

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자료유형: 학술저널

저자정보: Kim, Hye Young (Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute) Park, Min (Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute) Kim, Kyong (Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute) Lee, Yu Mi (Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute) Rhyu, Mee Ra (Metabolism and Nutrition Research Group, Division of Metabolism and Functionality Research, Korea Food Research Institute)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제2호

발행연도: 2013.1

수록면: 121 - 125 (5page)

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Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on suppressive effects on appetite. This study examined that hesperetin and hesperidin can stimulate the release of cholecystokinin (CCK), one of appetite-regulating hormones, from the enteroendocrine STC-1 cells, and then examined the mechanisms involved in the CCK release. Hesperetin significantly and dose-dependently stimulated CCK secretion with an $EC_{50}$ of 0.050 mM and increased the intracellular $Ca^{2+}$ concentrations ($[Ca^{2+}]_i$) compared to the untreated control. The stimulatory effect by hesperetin was mediated via the entry of extracellular $Ca^{2+}$ and the activation of TRP channels including TRPA1. These results suggest that hesperetin can be a candidate biomolecule for the suppression of appetite and eventually for the therapeutics of obesity.

#Hesperetin #Cholecystokinin #Intracellular $Ca^{2+}$ #TRP ankyrin 1 #Enteroendocrine cells

참고문헌 (16)

참고문헌 신청

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