지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 256 - 267 (12page)
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Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is currently available as a chemopreventive agent in women with high risk for breast cancer. The most challenging issue with tamoxifen use is the development of resistance in an initially responsive breast tumor. This review summarizes the roles of ER as the therapeutic target of tamoxifen in cancer treatment, clinical values and issues of tamoxifen use, and molecular mechanisms of tamoxifen resistance. Emerging knowledge on the molecular mechanisms of tamoxifen resistance will provide insight into the design of regimens to overcome tamoxifen resistance and discovery of novel therapeutic agents with a decreased chance of developing resistance as well as establishing more efficient treatment strategies.
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참고문헌 (130)
참고문헌 신청
Anderson, W. F. / 2002 / Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database / Breast Cancer Res. Treat 76:27~36
Angel, P. / 1991 / The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation / Biochim. Biophys. Acta 1072:129~157
Anzick, S. L. / 1997 / AIB1, a steroid receptor coactivator amplifi ed in breast and ovarian cancer / Science 277:965~968
Arpino, G. / 2007 / Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy / J. Natl. Cancer Inst 99:694~705
Banerjee, S. / 2003 / 17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway / Biochem. Biophys. Res. Commun 300:209~215
Angel, P. / 1991 / The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation / Biochim. Biophys. Acta 1072:129~157
Anzick, S. L. / 1997 / AIB1, a steroid receptor coactivator amplifi ed in breast and ovarian cancer / Science 277:965~968
Arpino, G. / 2007 / Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy / J. Natl. Cancer Inst 99:694~705
Banerjee, S. / 2003 / 17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway / Biochem. Biophys. Res. Commun 300:209~215
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