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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 340 - 345 (6page)
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초록· 키워드
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Sarsasapogenin (SAR) is a steroidal sapogenin that is used as starting material for the industrial synthesis of steroids. It has various pharmacological benefits, such as antitumor and antidepressant activities. Since its effect on melanin biosynthesis has not been reported, we used murine melanocyte melan-a cells to investigate whether SAR influences melanogenesis. In this study, SAR significantly increased the melanin content of the melan-a cells from 1 to 10 ${\mu}M$. Based on an enzymatic activity assay using melan-a cell lysate, SAR had no effect on tyrosinase and DOPAchrome tautomerase activities. It also did not affect the protein expression of tyrosinase-related protein 1 and DOPAchrome tautomerase. However, protein levels of tyrosinase and microphthalmia-associated transcription factor were strongly stimulated by treatment with SAR. Therefore, our reports suggest that SAR treatment may induce melanogenesis through the stimulation of tyrosinase and microphthalmia-associated transcription factor expression in melan-a cells.
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참고문헌 (6)
참고문헌 신청
Hearing, V. J. / 2000 / The melanosome: the perfect model for cellular responses to the environment / Pigment Cell Res 13(Suppl 8):23~34
Songhee Jeon/Nan-Hyung Kim / 2007 / Bee venom stimulates human melanocyte proliferation,melanogenesis, dendricity and migration / Experimental and Molecular Medicine 39(5):603~613
Kovacs, S. O. / 1998 / Vitiligo / J. Am. Acad. Dermatol 38:647~666
이종성 / 200502 / Glycyrrhizin induces melanogenesis by elevating a cAMP level in B16 melanoma cells / Journal of Investigative Dermatology 124(2):405~411
이종성 / 200706 / Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling / Life Sciences 81(3):249~254
Songhee Jeon/Nan-Hyung Kim / 2007 / Bee venom stimulates human melanocyte proliferation,melanogenesis, dendricity and migration / Experimental and Molecular Medicine 39(5):603~613
Kovacs, S. O. / 1998 / Vitiligo / J. Am. Acad. Dermatol 38:647~666
이종성 / 200502 / Glycyrrhizin induces melanogenesis by elevating a cAMP level in B16 melanoma cells / Journal of Investigative Dermatology 124(2):405~411
이종성 / 200706 / Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling / Life Sciences 81(3):249~254
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