지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 342 - 347 (6page)
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초록· 키워드
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In the present study, the anticonvulsant effects of Artemisia capillaris Herba (AC) and its major constituent, esculetin (ECT), were tested and the mechanism studied. Locomotion, Myorelaxation, motor coordination and electroshock seizure experiment were conducted in mice. To identify the anticonvulsant mechanism effect of this drug, chemical-induced seizure in mice and the ionic movement in neuroblastoma cells were also observed. The ethanol extract of AC was orally administered to mice 30 min. prior to testing and ECT was intraperitoneally injected. AC and ECT treatment did not change locomotor activities as well as activities on the rota-rod, which indicates that they did not cause a sedative and myorelaxation effect. AC and ECT treatment increased threshold of convulsion induced by electroshock. AC treatment also inhibited convulsion induced by pentylenetetrazole. In the case of strychnine however, only high dose of AC treatment inhibited convulsion. AC and ECT treatment increased the $Cl^-$ influx into the intracellular area in a dose-dependent manner. On the other hand, bicuculline, a GABA antagonist, inhibited the $Cl^-$ influx induced by AC and ECT. These results indicate that ECT induces the anticonvulsive effect of AC extract through the GABAergic neuron.
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참고문헌 (27)
참고문헌 신청
Browning, R. A. / 1990 / Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern / Epilepsy Res 6:1~11
Eisenberg, D. M. / 1998 / Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey / J . Am. Med. Assoc 280:1569~1575
Egan, D / 1990 / The pharmacology, metabolism, analysis and applications of coumarin and coumarin-related compo / Drug Metab. Rev 22:503~529
Farkas, S. / 2005 / Simple pharmacological test battery to assess effi cacy and side effect profi le of centrally acting muscle relaxant drugs / J. Pharmacol. Toxicol. Methods 52:264~273
Gidal, B. E. / 1999 / Alternative medicine (AM) use in epilepsy: results of a national, multicenter survey / Epilepsia 40(7):107~108
Eisenberg, D. M. / 1998 / Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey / J . Am. Med. Assoc 280:1569~1575
Egan, D / 1990 / The pharmacology, metabolism, analysis and applications of coumarin and coumarin-related compo / Drug Metab. Rev 22:503~529
Farkas, S. / 2005 / Simple pharmacological test battery to assess effi cacy and side effect profi le of centrally acting muscle relaxant drugs / J. Pharmacol. Toxicol. Methods 52:264~273
Gidal, B. E. / 1999 / Alternative medicine (AM) use in epilepsy: results of a national, multicenter survey / Epilepsia 40(7):107~108
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