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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 141 - 148 (8page)
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Osteoclasts are bone-resorbing cells of monocyte/macrophage origin and are culprits of bone destruction associated with osteoporosis, rheumatoid arthritis, and cancer bone metastasis. Recent advances in osteoclast biology revealed central roles of various cytokines in regulating osteoclastogenesis both in vitro and in vivo. However, exact underlying mechanisms including signaling pathways downstream of receptor ligation are still under pursuit. In the present review, the role of Jak/STAT proteins and their regulators will be discussed in connection with osteoclastogenesis, since growing evidence indicates that a number of cytokines and growth factors utilizing Jak/STAT signaling pathways affect osteoclastogenesis. A better understanding on the role of Jak/STAT pathways in osteoclast differentiation will not only strengthen our knowledge on osteoclast biology but also provide invaluable insights into the development of anti-resorptive strategies for treating bone-lytic diseases.
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참고문헌 (78)
참고문헌 신청
Abu-Amer, Y / 2001 / IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB / J. Clin. Invest 107:1375~1385
Ahlen, J / 2002 / Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones / Bone 31:242~251
Alexander, W. S / 2002 / Suppressors of cytokine signalling (SOCS) in the immune system / Nat. Rev. Immunol 2:410~416
Arai, F / 1999 / Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors / J. Exp. Med 190:1741~1754
Arora, T. / 2003 / PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4 / J. Biol. Chem 278:21327~21330
Ahlen, J / 2002 / Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones / Bone 31:242~251
Alexander, W. S / 2002 / Suppressors of cytokine signalling (SOCS) in the immune system / Nat. Rev. Immunol 2:410~416
Arai, F / 1999 / Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors / J. Exp. Med 190:1741~1754
Arora, T. / 2003 / PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4 / J. Biol. Chem 278:21327~21330
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