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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 70 - 76 (7page)
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초록· 키워드
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Bone remodeling is a dynamic process involving a constant balance between osteoclast-induced bone resorption and osteoblast-induced bone formation. Osteoclasts play a crucial homeostatic role in skeletal modeling and remodeling, and destroy bone in many pathological conditions. Previously, we reported that the hexane soluble fraction of Ficus carica inhibited osteoclast differentiation. Poly unsaturated fatty acids, such as ethyl docosahexaenoate (E-DHA), docosahexaenoic acid (DHA), cis-11,14-eicosadienoic acid (EDA) and eicosapentaenoic acid (EPA), were identified from the hexane soluble fraction of Ficus carica. Among them, E-DHA most potently inhibited osteoclastogenesis in RAW264.7 cells. E-DHA reduced the activities of JNK and NF-$\kappa}B$. E-DHA suppressed the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Interestingly, DHA increased the activity of alkaline phosphatase and expression of bone morphogenetic protein 2 (BMP2) more than E-DHA in MC3T3-E1 cells, suggesting that DHA may induce osteoblast differentiation. The data suggests that a combination of E-DHA and DHA has potential use in the treatment of diseases involving abnormal bone lysis, such as osteoporosis, rheumatoid arthritis and periodontal bone erosion.
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참고문헌 (27)
참고문헌 신청
Calder, P. C / 2001 / Poryunsaturated fatty acids and rheumatoid arthritis / Curr. Opin. Clin. Nutr. Metab. Care 4:115~121
Choi, H. J / 2010 / Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-kappaB signaling pathways / Eur. J. Pharmacol 636:28~35
Hudert, C. A / 2006 / Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis / Proc. Natl. Acad. Sci. USA 103:11276~11281
Kobayashi, N / 2001 / Segregation of TRAF6-mediated signaling pathways clarifi es its role in osteoclastogenesis / EMBO J 20:1271~1280
Lee, S. E / 2002 / The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation / Bone 30:71~77
Choi, H. J / 2010 / Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-kappaB signaling pathways / Eur. J. Pharmacol 636:28~35
Hudert, C. A / 2006 / Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis / Proc. Natl. Acad. Sci. USA 103:11276~11281
Kobayashi, N / 2001 / Segregation of TRAF6-mediated signaling pathways clarifi es its role in osteoclastogenesis / EMBO J 20:1271~1280
Lee, S. E / 2002 / The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation / Bone 30:71~77
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