지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 134 - 139 (6page)
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Sphingosine kinase (SPHK) has a central role to control cell death and cell proliferation, which is suggested as a sphingolipid rheostat by regulating the levels between ceramide and sphingosine 1-phosphate (S1P). Therefore, physiological regulators of SPHK will be a good candidate to develop a new targeted drug. For this purpose, a series of synthetic pseudoceramides were tested by SPHK assay either cell-based or cell-free system. K10PC-5 strongly inhibited SPHK, while K6PC-5 activated SPHK in cell-free system. Specifically, K6PC-5 activated SPHK under the co-treatment with $50\;{\mu}M$ dimethylsphingosine (DMS), a SPHK inhibitor. Collectively, we developed a simple SPHK assay system to find SPHK regulatory pseudoceramide compounds, K10PC-5 and K6PC-5 which may be useful to cancer treatment or immune regulation like FTY720, a synthetic sphingolipid mimetic compound.
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참고문헌 (27)
참고문헌 신청
Billich, A / 2003 / Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases / J. Biol. Chem 278:47408~47415
Brinkmann, V / 2009 / FTY720 (fi ngolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system / Br. J. Pharmacol 158:1173~1182
Claus, R / 2000 / Modulation of the ceramide level, a novel therapeutic concept / Curr. Drug Targets 1:185~205
Hannun, Y. A / 1995 / Ceramide: an intracellular signal for apoptosis / Trends Biochem. Sci 20:73~77
Hengst, J. A / 2010 / Development of a sphingosine kinase 1 specifi c smallmolecule inhibitor / Bioorg. Med. Chem. Lett 20:7698~74502
Brinkmann, V / 2009 / FTY720 (fi ngolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system / Br. J. Pharmacol 158:1173~1182
Claus, R / 2000 / Modulation of the ceramide level, a novel therapeutic concept / Curr. Drug Targets 1:185~205
Hannun, Y. A / 1995 / Ceramide: an intracellular signal for apoptosis / Trends Biochem. Sci 20:73~77
Hengst, J. A / 2010 / Development of a sphingosine kinase 1 specifi c smallmolecule inhibitor / Bioorg. Med. Chem. Lett 20:7698~74502
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