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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 441 - 444 (4page)
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The aim of present study was to isolate a bioactive compound from the chloroform fraction of Ephedra pachyclada stems and to evaluate antidiabetic activities against ${\alpha}$-glucosidase and ${\alpha}$-amylase. According to various chromatographic and spectroscopic analyses, the bioactive compound of E. pachyclada was identified as quinoline-2-carboxylic acid. Based on the $IC_{50}$ values of quinoline-2-carboxylic acid derivatives against ${\alpha}$-glucosidase and ${\alpha}$-amylase, quinoline-2-carboxylic acid (9.1 and $15.5{\mu}g/mL$) exhibited potent inhibitory activities, followed by quinoline-3-carboxylic acid (10.6 and $31.4{\mu}g/mL$), quinoline-4-carboxylic acid (60.2 and $152.4{\mu}g/mL$), and acarbose (66.5 and $180.6{\mu}g/mL$) against ${\alpha}$-glucosidase and ${\alpha}$-amylase, respectively. However, quinoline-2-carboxaldehyde, quinoline-3-carboxaldehyde, and quinoline-4-carboxaldehyde showed no inhibitory activities. Antidiabetic activity depended on the existence of a carboxyl group on quinoline for activities against ${\alpha}$-glucosidase and ${\alpha}$-amylase. Therefore, E. pachyclada and quinoline-2-carboxylic acid derivatives could be suitable as alternative synthetic antidiabetic agents.
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