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논문 기본 정보

자료유형
학술저널
저자정보
Tampus, Reinholdgher (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University) Yoon, Seong Shoon (Center for Safety Pharmacology, Korea Institute of Toxicology) Pena, June Bryan de la (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University) Botanas, Chrislean Jun (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University) Kim, Hee Jin (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University) Seo, Joung-Wook (Center for Safety Pharmacology, Korea Institute of Toxicology) Jeong, Eun Ju (Center for Safety Pharmacology, Korea Institute of Toxicology) Jang, Choon Gon (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University) Cheong, Jae Hoon (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제23권 제6호
발행연도
2015.1
수록면
590 - 596 (7page)

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The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown to have abuse liability and were subsequently regulated by authorities. However, there are compounds that are still not regulated probably due to the lack of abuse liability studies. In the present study, we assessed the abuse liability of three synthetic cannabinoids, namely JWH-030, JWH-175, and JWH-176. The abuse liability of these drugs was evaluated in two of the most widely used animal models for assessing the abuse potential of drugs, the conditioned place preference (CPP) and self-administration (SA) test. In addition, the open-field test was utilized to assess the effects of repeated (7 days) treatment and abrupt cessation of these drugs on the psychomotor activity of animals. Results showed that JWH-175 (0.5 mg/kg), but not JWH-030 or JWH-176 at any dose, significantly decreased the locomotor activity of mice. This alteration in locomotor activity was only evident during acute exposure to the drug and was not observed during repeated treatment and abstinence. Similarly, only JWH-175 (0.1 mg/kg) produced significant CPP in rats. On the other hand, none of the drugs tested was self-administered by rats. Taken together, the present results indicate that JWH-175, but not JWH-030 and JWH-176, may have abuse potential. More importantly, our findings indicate the complex psychopharmacological effects of synthetic cannabinoids and the need to closely monitor the production, dispensation, and use of these substances.
#Cannabis #Synthetic cannabinoids #JWH #Abuse #Self-administration #Conditioned place preference

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참고문헌 (34)

참고문헌 신청
Auwärter, V. / 2009 / ‘Spice’and other herbal blends: harmless incense or cannabinoid designer drugs? / J. Mass. Spectrom 44:832~837 google schola Botanas, C. J. / 2015 / Methoxetamine, a ketamine derivative, produced conditioned place preference and was self-administered by rats: Evidence of its abuse potential / Pharmacol. Biochem. Behav 133:31~36 google schola Braida, D. / 2004 / Δ 9-Tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats / Eur. J. Pharmacol 506:63~69 google schola Brents, L. K. / 2011 / Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity / PLoS One 6:e21917 google schola Chaperon, F. / 1998 / Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats / Psychopharmacology 135:324~332 google schola

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