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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 324 - 330 (7page)
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초록· 키워드
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Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders, especially respiratory inflammation, in Chinese medicine. Previously, phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-inflammatory activity in vitro and in vivo. In this study, the effects of BL on lung inflammation including bronchitis were examined in vitro and in vivo. BL (10-100 ${\mu}g$/ml) inhibited nitric oxide (NO) production of lipopolysaccharide (LPS)-treated alveolar macrophages, MH-S cells, primarily by down-regulating inducible NO synthase. BL also inhibited production of the proinflammatory cytokines, TNF-${\alpha}$ and IL-6. Against an animal model of pleural cavity inflammation, BL (200-400 mg/kg) significantly inhibited 5 h and 24 h carrageenan-induced pleurisy in rats when administered orally. Additionally, BL inhibited experimental bronchitis induced by intratracheal instillation of LPS to rats. Taken together, these results indicate that BL may be effective for the treatment of human lung inflammation as well as bronchitis.
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참고문헌 (23)
참고문헌 신청
Batt, D. G / 1992 / 5-Lipoxygenase inhibitors and their anti-infl ammatory activities / Prog. Med. Chem 29:1~63
Cheng, Z. J. / 2001 / Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages / Biochem. Pharmacol 61:939~946
Chi, Y. S / 2001 / Effect of wogonin, a plant fl avone from Scutellaria radix, on the suppression of cyclooxygenase and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells / Biochem. Pharmacol 61:1195~1203
Chi, Y. S. / 2001 / Effects of naturally occurring prenylated fl avonoids on arachidonic acid metabolizing enzymes: Cyclooxygenases and lipoxygenases / Biochem. Pharmacol 62:1185~1191
Cuzzocrea, S. / 2003 / 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan / J. Leukoc. Biol 73:739~746
Cheng, Z. J. / 2001 / Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages / Biochem. Pharmacol 61:939~946
Chi, Y. S / 2001 / Effect of wogonin, a plant fl avone from Scutellaria radix, on the suppression of cyclooxygenase and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells / Biochem. Pharmacol 61:1195~1203
Chi, Y. S. / 2001 / Effects of naturally occurring prenylated fl avonoids on arachidonic acid metabolizing enzymes: Cyclooxygenases and lipoxygenases / Biochem. Pharmacol 62:1185~1191
Cuzzocrea, S. / 2003 / 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan / J. Leukoc. Biol 73:739~746
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