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- 학술저널
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- 2011.1
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- 21 - 26 (6page)
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Ceramide is an important lipid mediator of extracellular signals that control various cellular functions, including apoptosis. In this study, we showed that ceramide induced apoptosis in U373MG human glioblastoma cells associated with G1 cell cycle arrest. Treatment of cells with ceramide increased proapoptotic Bax expression and inhibited the expression of antiapoptotic Bcl-2 and Bcl-xL Ceramide also downregulated cyclin E, cyclin D1, cdk 2, and cdk4 which are involved in regulating cell cycle. In addition, ceramide suppressed phosphorylation of Akt, Bad, p70 S6 kinase, and 4E-BP1, suggesting the involvement of Akt/mTOR signaling pathway. Additionally, okadaic acid, an inhibitor of protein phosphatase 2A, partially blocked the ceramide mediated inhibition of phosphorylation of Akt and 4E-BP1. These results suggest that ceramide induces apoptosis in U373MG glioblastoma cells by regulating multiple signaling pathways that involve cell cycle arrest associated with Akt signaling pathway.
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참고문헌 (40)
참고문헌 신청
Armengol, G / 2007 / 4E-binding protein / Cancer Res 67:7551~7555
Barnhart, B. C / 2008 / Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival / Cancer Biol. Ther 7:1441~1449
Bieberich, E. / 2000 / N-acylated serinol is a novel cermide mimic inducing apoptosis in neuroblastoma cells / J. Biol. Chem 275:177~181
Brunet, A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkead transcription factor / Cell 96:857~868
Cabot, M. / 1999 / DZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitivity and drug-resistance cancer cells / Cancer Res 59:880~885
Barnhart, B. C / 2008 / Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival / Cancer Biol. Ther 7:1441~1449
Bieberich, E. / 2000 / N-acylated serinol is a novel cermide mimic inducing apoptosis in neuroblastoma cells / J. Biol. Chem 275:177~181
Brunet, A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkead transcription factor / Cell 96:857~868
Cabot, M. / 1999 / DZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitivity and drug-resistance cancer cells / Cancer Res 59:880~885
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