The Influence of Circadian Gene Per2 on Cell Damaged by Ultraviolet C

Liu, Yanyou; Wang, Yuhui; Jiang, Zhou; Xiao, Jing; Wang, Zhengrong

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자료유형: 학술저널

저자정보: Liu, Yanyou (Key Laboratory of Chronobiology, Ministry of Health [Sichuan University], West China School of Preclinical and Forensic Medicine) Wang, Yuhui (Key Laboratory of Chronobiology, Ministry of Health [Sichuan University], West China School of Preclinical and Forensic Medicine) Jiang, Zhou (Key Laboratory of Chronobiology, Ministry of Health [Sichuan University], West China School of Preclinical and Forensic Medicine) Xiao, Jing (Key Laboratory of Chronobiology, Ministry of Health [Sichuan University], West China School of Preclinical and Forensic Medicine) Wang, Zhengrong (Key Laboratory of Chronobiology, Ministry of Health [Sichuan University], West China School of Preclinical and Forensic Medicine)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제19권 제3호

발행연도: 2011.1

수록면: 308 - 314 (7page)

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It has been shown that circadian genes not only play an important role on circadian rhythms, but also participate in other physiological and pathological activities, such as drug dependence, cancer development and radiation injury. The Per2, an indispensable component of the circadian clock, not only modulates circadian oscillations, but also regulates organic function. In the present study, we applied mPER2-upregulated NIH3T3 cells to reveal the relationship of mPer2 and the cells damaged by ultraviolet C (UVC). NIH3T3 cells at the peak of the expression of mPer2 induced by phorbol 12-myristate 13-acetate (PMA) demonstrated little damage by UVC evaluated by MTT assay, cell growth curves and cell colony-forming assay, compared with that at the nadir of the expression of mPer2. Overexpression of mPER2, accompanied p53 upregulated, also demonstrated protective effect on NIH3T3 cells damaged by UVC. These results suggest that mPer2 plays a protective effect on cells damaged by UVC, whose mechanism may be involved in upregulated p53.

#Circadian #mPer2 #p53 #ultraviolet C #DNA damage

참고문헌 (44)

참고문헌 신청

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