Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice

Kwon, Seung-Hwan; Ma, Shi-Xun; Joo, Hyun-Joong; Lee, Seok-Yong; Jang, Choon-Gon

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저자정보: Kwon, Seung-Hwan (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University) Ma, Shi-Xun (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University) Joo, Hyun-Joong (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University) Lee, Seok-Yong (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University) Jang, Choon-Gon (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제6호

발행연도: 2013.1

수록면: 462 - 469 (8page)

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Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the effects of EUE aqueous extract in graded doses to protect and enhance cognition in scopolamine-induced learning and memory impairments in mice. EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. One day after the last trial session of the Morris water maze test (probe trial session), EUE dramatically increased the latency time in the target quadrant in a dose-dependent manner. Furthermore, EUE significantly inhibited acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner. EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice. Based on these findings, we suggest that EUE may be useful for the treatment of cognitive deficits, and that the beneficial effects of EUE are mediated, in part, by cholinergic signaling enhancement and/or protection.

#Eucommia ulmoides Oliv #Bark #Scopolamine #Learning and memory #Brain-derived neurotrophic factor #cAMP element binding protein #Alzheimer's disease

참고문헌 (37)

참고문헌 신청

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