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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 411 - 422 (12page)
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G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets. New technologies have been developed for the identification of new ligands, new GPCR functions, and for drug discovery purposes. In particular, intercellular lipid mediators, such as, lysophosphatidic acid and sphingosine 1-phosphate have attracted much attention for drug discovery and this has resulted in the development of fingolimod (FTY-720) and AM095. The discovery of new intercellular lipid mediators and their GPCRs are discussed from the perspective of drug development. Lipid GPCRs for lysophospholipids, including lysophosphatidylserine, lysophosphatidylinositol, lysophosphatidylcholine, free fatty acids, fatty acid derivatives, and other lipid mediators are reviewed.
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참고문헌 (145)
참고문헌 신청
Arterburn, J. B. / 2009 / Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30 / Curr. Top. Med. Chem 9:1227~1236
Baker, D. / 2006 / In silico patent searching reveals a new cannabinoid receptor / Trends Pharmacol. Sci 27:1~4
Benned-Jensen, T. / 2010 / Distinct expression and ligand-binding profi les of two constitutively active GPR17 splice variants / Br. J. Pharmacol 159:1092~1105
Bratton, D. L. / 2008 / Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? / Curr. Biol 18:76~79
Bresnick, J. N. / 2003 / Identifi cation of signal transduction pathways used by orphan g protein-coupled receptors / Assay Drug Dev. Technol 1:239~249
Baker, D. / 2006 / In silico patent searching reveals a new cannabinoid receptor / Trends Pharmacol. Sci 27:1~4
Benned-Jensen, T. / 2010 / Distinct expression and ligand-binding profi les of two constitutively active GPR17 splice variants / Br. J. Pharmacol 159:1092~1105
Bratton, D. L. / 2008 / Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? / Curr. Biol 18:76~79
Bresnick, J. N. / 2003 / Identifi cation of signal transduction pathways used by orphan g protein-coupled receptors / Assay Drug Dev. Technol 1:239~249
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