지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 405 - 410 (6page)
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Codonopsis lanceolata (Campanulaceae) traditionally have been used as a tonic and to treat patients with lung abscesses. Recently, it was proposed that the extract and some compounds isolated from C. lanceolata reversed scopolamine-induced memory and learning deficits. The purpose of this study was to evaluate the improvement of cognitive enhancing effect of C. lanceolata by steam and fermentation process in scopolamine-induced memory impairment mice models by passive avoidance test and Morris water maze test. The extract of C. lanceolata or the extract of steamed and fermented C. lanceolata (SFCE) was orally administered to male mice at the doses of 100 and 300 mg/kg body weight. As a result, mice treated with steamed and fermented C. lanceolata extract (SFCE) (300 mg/kg body weight, p.o.) showed shorter escape latencies than those with C. lanceolata extract or the scopolamine-administered group in Morris water maze test. Also, it exerted longer step-through latency time than scopolamine treated group in passive avoidance test. Furthermore, neuroprotective effect of SFCE on glutamate-induced cytotoxicity was assessed in HT22 cells. Only SFCE-treated cells showed significant protection at 500 ${\mu}g/ml$. Interestingly, steamed C. lanceolata with fermentation contained more phenolic acid including gallic acid and vanillic acid than original C. lanceolata. Collectively, these results suggest that steam and fermentation process of C. lanceolata increased cognitive enhancing activity related to the memory processes and neuroprotective effect than original C. lanceolata.
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참고문헌 (35)
참고문헌 신청
Bains, J. S. / 1997 / Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death / Brain Res. Brain Res. Rev 25:335~358
Ban, J. Y. / 2008 / Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons / Biol. Pharm. Bull 31:149~153
Brion, J. P. / 1998 / Neurofi brillary tangles and Alzheimer's disease / Eur. Neurol 40:130~140
Brookmeyer, R. / 1998 / Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset / Am. J. Public Health 88:1337~1342
Se Eun Byeon / 2009 / Inhibitory Effect of Saponin Fraction from Codonopsis lanceolata on Immune Cell-Mediated Inflammatory Responses / Archives of Pharmacal Research 32(6):813~822
Ban, J. Y. / 2008 / Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons / Biol. Pharm. Bull 31:149~153
Brion, J. P. / 1998 / Neurofi brillary tangles and Alzheimer's disease / Eur. Neurol 40:130~140
Brookmeyer, R. / 1998 / Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset / Am. J. Public Health 88:1337~1342
Se Eun Byeon / 2009 / Inhibitory Effect of Saponin Fraction from Codonopsis lanceolata on Immune Cell-Mediated Inflammatory Responses / Archives of Pharmacal Research 32(6):813~822
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