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논문 기본 정보

자료유형
학술저널
저자정보
Sohn, Ki Cheul (Department of Preventive Medicine, School of Medicine, Catholic University of Daegu) Kang, Su Jin (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University) Kim, Joo Wan (Glucan Corporation and Marine Bio-Industry Development Center) Kim, Ki Young (Glucan Corporation and Marine Bio-Industry Development Center) Ku, Sae Kwang (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University) Lee, Young Joon (The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제4호
발행연도
2013.1
수록면
290 - 298 (9page)

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This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-${\alpha}$, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.

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