지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 196 - 200 (5page)
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Role of metabolism by intestinal bacteria in arbutin-induced immunotoxicity was investigated in splenocyte cultures. Following an incubation of arbutin with 5 different intestinal bacteria for 24 hr, its aglycone hydroquinone could be produced and detected in the bacterial culture media with different amounts. Toxic effects of activated arbutin by intestinal bacteria on lymphoproliferative response were tested in splenocyte cultures from normal mice. Lipopolysaccharide and concanavalin A were used as mitogens for B- and T-cells, respectively. When bacteria cultured medium with arbutin was treated into the splenocytes for 3 days, the medium cultured with bacteria producing large amounts of hydroquinone induced suppression of lymphoproliferative responses, indicating that metabolic activation by intestinal bacteria might be required in arbutin-induced toxicity. The results indicated that the present testing system might be applied for determining the possible role of metabolism by intestinal bacteria in certain chemical-induced immunotoxicity in animal cell cultures.
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참고문헌 (13)
참고문헌 신청
Blaut, M. / 2006 / Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria / Food. Chem. Toxicol 44:1940~1947
Deisinger, P. J. / 1996 / Human exposure to naturally occurring hydroquinone / J. Toxicol. Environ. Health 47:31~46
Gorbach, S. L. / 1967 / Studies of intestinal microfl ora. I. Effects of diet, age, and periodic sampling on numbers of fecal microorganisms in man / Gastroenterology 53:845~855
Jin, M. J. / 2010 / Effects of gut microfl ora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudogerm- free rats. / J. Toxicol. Environ. Health. A 73:1441~1450
Mi Jeong Kang / 2011 / Role of Metabolism by Intestinal Bacteria in Arbutin-induced Toxicity In Vitro / Archives of Pharmacal Research 34(4):687~693
Deisinger, P. J. / 1996 / Human exposure to naturally occurring hydroquinone / J. Toxicol. Environ. Health 47:31~46
Gorbach, S. L. / 1967 / Studies of intestinal microfl ora. I. Effects of diet, age, and periodic sampling on numbers of fecal microorganisms in man / Gastroenterology 53:845~855
Jin, M. J. / 2010 / Effects of gut microfl ora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudogerm- free rats. / J. Toxicol. Environ. Health. A 73:1441~1450
Mi Jeong Kang / 2011 / Role of Metabolism by Intestinal Bacteria in Arbutin-induced Toxicity In Vitro / Archives of Pharmacal Research 34(4):687~693
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