메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Kang, Jung-Il (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Kim, Sang-Cheol (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Han, Sang-Chul (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Hong, Hye-Jin (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Jeon, You-Jin (Aqua Green Technology Co.) Kim, Bo-Ra (Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics) Koh, Young-Sang (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Yoo, Eun-Sook (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University) Kang, Hee-Kyoung (Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제20권 제1호
발행연도
2012.1
수록면
118 - 124 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
This study was conducted to evaluate the effect of Grateloupia elliptica, a seaweed native to Jeju Island, Korea, on the prevention of hair loss. When immortalized rat vibrissa dermal papilla cells were treated with extract of G. elliptica, the proliferation of dermal papilla cells significantly increased. In addition, the G. elliptica extract significantly inhibited the activity of $5{\alpha}$-reductase, which converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia. On the other hand, the G. elliptica extract promoted $PGE_2$ production in HaCaT cells in a dose-dependent manner. The G. elliptica extract exhibited particularly high inhibitory effect on LPS-stimulated IL-12, IL-6, and TNF-${\alpha}$ production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. The G. elliptica extract also showed inhibitory activity against Pityrosporum ovale, a main cause of dandruff. These results suggest that G. elliptica extract has the potential to treat alopecia via the proliferation of dermal papilla, $5{\alpha}$-reductase inhibition, increase of $PGE_2$ production, decrease of LPS-stimulated pro-inflammatory cytokines and inhibitory activity against Pityrosporum ovale.

목차

등록된 정보가 없습니다.

참고문헌 (48)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0