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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 348 - 356 (9page)
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Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodigenerative disorders, obesity and diabetes. The aims of this study were to study the antidiabetic effects of the aqueous extract of L. platyphylla (AEtLP) through pancreatic and extrapancreatic actions. AEtLP were orally administrated to ICR mice once a day for 7 days. Of three different concentrations of AEtLP, only 10% AEtLP were low toxic to liver, based on body weight and serum biochemical analyses. However, 10% AEtLP-treated mice displayed signifi cant reduction of the glucose concentration and increased insulin concentration; no changes were noted using 5% and 15% AEtLP. Also, the increase of glucose transporter (Glut)-1 expression in liver was dependent on the concentration of AEtLP, and was regulated by the phosphorylation of Akt. The lowest expression of Glut-3 was observed in 15% AEtLP treated mice, followed by 10% AEtLP- and 5% AEtLP-treated mice. This pattern of Glut-3 expression was roughly in accord with the phosphorylation of c-Jun N-teminal kinase (JNK) in the mitogen-activated protein kinase (MAPK) pathway. Furthermore, a signifi cant rise of the superoxide dismutase activity (SOD) was detected in AEtLP-treated mice. The fi ndings suggest that AEtLP should be considered as a diabetes therapeutic candidate to induce insulin secretion from pancreatic ${\beta}$-cells and glucose uptake in liver cells.
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참고문헌 (25)
참고문헌 신청
Atalay, M / 2002 / Diabetes, oxidative stress and physical exercise / J. Sports Sci. Med 1:1~14
Choi, S. B / 2002 / A steroidal glycoside from Polygonatum (Mill.) odoratum Druce improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats / Biosci. Biotech. Biochem 66:2036~2043
Choi, S. B / 2004 / The insulin sensitizing effect of homoisofl avone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75:2653~2664
Czech, M. P / 1999 / Signaling mechanisms that regulate glucose transport / J. Biol. Chem 274:1865~1868
Shipra Gupta / 2010 / Elucidation of Mechanism of Action of Cassia auriculata Leaf Extract for Its Antidiabetic Activity in Streptozotocin-Induced Diabetic Rats / Journal of Medicinal Food 13(3):528~534
Choi, S. B / 2002 / A steroidal glycoside from Polygonatum (Mill.) odoratum Druce improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats / Biosci. Biotech. Biochem 66:2036~2043
Choi, S. B / 2004 / The insulin sensitizing effect of homoisofl avone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway / Life Sci 75:2653~2664
Czech, M. P / 1999 / Signaling mechanisms that regulate glucose transport / J. Biol. Chem 274:1865~1868
Shipra Gupta / 2010 / Elucidation of Mechanism of Action of Cassia auriculata Leaf Extract for Its Antidiabetic Activity in Streptozotocin-Induced Diabetic Rats / Journal of Medicinal Food 13(3):528~534
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