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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 315 - 319 (5page)
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Galanin (Gal) is a 29-amino-acid neuropeptide which is expressed in superior cervical ganglion (SCG) neurons and plays a trophic role in the adult animal and acts as an inhibitory modulator of cholinergic and noradrenergic neurotransmission. Whether activation or inhibition of alpha-adrenoreceptors infl uences Gal mRNA expression in SCG neurons remains unknown. Here, we have evaluated the possible regulation of Gal mRNA expression with acute (4 h) and chronic (4 days) stimulation of alpha 1- and alpha 2-adrenoreceptor agonists or antagonists in primary cultured SCG neurons. The results showed that the amount of Gal mRNA expression in cultured SCG neurons increased signifi cantly after chronic stimulation with alpha 2-adrenoreceptor antagonist yohimbine compared with control SCG neurons at the same time point, whereas the amount of Gal mRNA expression decreased signifi cantly after chronic stimulation with alpha 2-adrenoreceptor agonist clonidine as compared with that in control group. All these effects were not dose-dependent on the administration of alpha 2-adrenoreceptor agonist clonidine or alpha 2-adrenoreceptor antagonist yohimbine. Alpha 1-adrenoreceptor agonist phenylephrine or antagonist prazosin chronic stimulation did not have effects on Gal mRNA expression. Acute exposure of these agents did not have effects on Gal mRNA expression. The present study showed that Gal may be regulated by activation or inhibition of alpha 2-adrenoreceptors, but not alpha 1-adrenoreceptors in sympathetic neurons.
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참고문헌 (32)
참고문헌 신청
Barrera, G / 2006 / Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals / Synapse 59:27~40
Boehm, S / 1997 / Receptors controlling transmitter release from sympathetic neurons in vitro / Prog. Neurobiol 51:225~242
Brum, P. C. / 2006 / Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons / Neuropharmacology 51:397~413
Brumovsky, P / 2006 / Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing / J. Chem. Neuroanat 31:243~262
Chen, Q / 2006 / Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons / J. Pharmacol. Exp. Ther 316:733~742
Boehm, S / 1997 / Receptors controlling transmitter release from sympathetic neurons in vitro / Prog. Neurobiol 51:225~242
Brum, P. C. / 2006 / Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons / Neuropharmacology 51:397~413
Brumovsky, P / 2006 / Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing / J. Chem. Neuroanat 31:243~262
Chen, Q / 2006 / Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons / J. Pharmacol. Exp. Ther 316:733~742
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