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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 425 - 430 (6page)
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초록· 키워드
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In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinflammatory cytokines, interleukin $1{\beta}$, tumor necrosis factor ${\alpha}$ and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinflammation.
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참고문헌 (27)
참고문헌 신청
Awale, S. / 2006 / Identifi cation of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation / Cancer Res 66:1751~1757
Banati, R. B. / 1993 / Cytotoxicity of microglia / Glia 7:111~118
Boje, K. M / 1992 / Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death / Brain Res 587:250~256
Choi, I. Y / 2007 / Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models / IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 43:215~221
Frotscher, M / 1990 / Plasticity of identifi ed neurons in slice cultures of hippocampus: a combined Golgi/ electron microscopic and immunocytochemical study / Prog. Brain Res 83:323~339
Banati, R. B. / 1993 / Cytotoxicity of microglia / Glia 7:111~118
Boje, K. M / 1992 / Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death / Brain Res 587:250~256
Choi, I. Y / 2007 / Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models / IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 43:215~221
Frotscher, M / 1990 / Plasticity of identifi ed neurons in slice cultures of hippocampus: a combined Golgi/ electron microscopic and immunocytochemical study / Prog. Brain Res 83:323~339
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