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논문 기본 정보

자료유형
학술저널
저자정보
Shanta, Selina Rahman (Department of Molecular Biotechnology, WCU Program, Konkuk University) Kim, Young-Jun (Department of Applied Biochemistry, Konkuk University) Kim, Young-Hwan (Division of Mass Spectrometry Research, Korea Basic Science Institute) Kim, Kwang-Pyo (Department of Molecular Biotechnology, WCU Program, Konkuk University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제19권 제2호
발행연도
2011.1
수록면
149 - 154 (6page)

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Matrix assisted laser desorption ionization (MALDI) mass spectrometry is commonly used to analyze biological molecules such as proteins, peptides and lipids from cells or tissue. Recently MALDI Imaging mass spectrometry (IMS) has been widely applied for the identification of different drugs and their metabolites in tissue. This special feature has made MALDI-MS a common choice for investigation of the molecular histology of pathological samples as well as an important alternative to other conventional imaging methods. The basic advantages of MALDI-IMS are its simple technique, rapid acquisition, increased sensitivity and most prominently, its capacity for direct tissue analysis without prior sample preparation. Moreover, with ms/ms analysis, it is possible to acquire structural information of known or unknown analytes directly from tissue sections. In recent years, MALDI-IMS has made enormous advances in the pathological field. Indeed, it is now possible to identify various changes in biological components due to disease states directly on tissue as well as to analyze the effect of treated drugs. In this review, we focus on the advantages of MALDI tissue imaging over traditional methods and highlight some motivating findings that are significant in pathological studies.

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