지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 299 - 306 (8page)
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초록· 키워드
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In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice were treated with EEZS. The behavioral tests were conducted using the passive avoidance, the Y-maze, and the Morris water maze tasks. EEZS (100 or 200 mg/kg, p.o.) significantly ameliorated the scopolamine-induced cognitive impairment in our present behavioral tasks without changes of locomotor activity. The ameliorating effect of EEZS on scopolamine-induced memory impairment was significantly reversed by a sub-effective dose of MK-801 (0.0125 mg/kg, s.c.). In addition, single administration of EEZS in normal naive mouse enhanced latency time in the passive avoidance task. Western blot analysis was employed to confirm the mechanism of memory-ameliorating effect of EEZS. Administration of EEZS (200 mg/kg) increased the level of memory-related signaling molecules, including phosphorylation of extracellular signal-regulated kinase or cAMP response element-binding protein in the hippocampal region. Also, the time-dependent expression level of brain-derived neurotrophic factor by the administration of EEZS was markedly increased from 3 to 9 h. These results suggest that EEZS has memory-ameliorating effect on scopolamine-induced cognitive impairment, which is mediated by the enhancement of the cholinergic neurotransmitter system, in part, via NMDA receptor signaling, and that EEZS would be useful agent against cognitive dysfunction such as Alzheimer's disease.
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참고문헌 (39)
참고문헌 신청
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Bourtchuladze, R. / 1994 / Defi cient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein / Cell 79:59~68
Cao, J. X. / 2010 / Hypnotic effect of jujubosides from Semen Ziziphi Spinosae / J. Ethnopharmacol 130:163~166
Chen, C. Y. / 2008 / What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation / J. Biomol. Struct. Dyn 26:57~64
Birks, J. S / 2000 / Donepezil for mild and moderate Alzheimer's disease / Cochrane Database Syst. Rev :CD001190
Bourtchuladze, R. / 1994 / Defi cient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein / Cell 79:59~68
Cao, J. X. / 2010 / Hypnotic effect of jujubosides from Semen Ziziphi Spinosae / J. Ethnopharmacol 130:163~166
Chen, C. Y. / 2008 / What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation / J. Biomol. Struct. Dyn 26:57~64
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