지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 231 - 236 (6page)
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초록· 키워드
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The aim of this study was to investigate the effect of charge carrier lipid on the skin penetration, retention, and hair growth of topically applied finasteride-containing liposomes. Finasteride-containing liposomes were prepared by traditional thin film hydration method using Phospholipon$^{(R)}$ 85 G and cholesterol with or without charge carrier lipid (1,2 dimyristoyl-sn-glycero-3-phosphate or 1,2-dioleoyl-trimethylammonium-propane for anionic and cationic charge, respectively). Freshly prepared finasteride-containing liposome suspension was applied on the hairless mouse skin, and skin penetration and retention were measured using Keshary-Chien diffusion cell. Non-liposomal formulation (ethanol 10% solution containing 0.5 mg/ml of FNS) was also used as a control. The amount of finasteride in the diffusion cell and mouse skin was measured by HPLC. The hair growth was evaluated using depilated male C57BL/6N mice. Mean particle size of all finasteride-containing liposomes was less than a micron, and polydispersity index revealed size homogeneity. Skin penetration and retention studies showed that significantly less amount of finasteride was penetrated when applied as anionic liposome while more amount of the drug was retained. Specifically, in liposome prepared with 10% anionic charge carrier lipid, penetration was 12.99 ${\mu}g/cm^2$ while retention was 79.23 ${\mu}g/cm^2$ after 24 h of application. In hair growth study, finasteride-containing anionic liposomes showed moderate efficacy, but the efficacy was not found when applied as cationic liposomes. In conclusion, topical application of finasteride using anionic liposome formulation appears to be useful option for the treatment of androgenetic alopecia to avoid systemic side effects of the drug.
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참고문헌 (25)
참고문헌 신청
Allen, T. M / 1991 / Uptake of liposomes by cultured mouse bone marrow macrophages: infl uence of liposome composition and size / Biochim. Biophys. Acta 1061:56~64
Balakrishnan, P / 2009 / Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery / INTERNATIONAL JOURNAL OF PHARMACEUTICS 377:1~8
Biruss, B / 2007 / The infl uence of selected steroid hormones on the physicochemical behavior of DPPC liposomes / Chem. Phys. Lipids 148:84~90
Biruss, B / 2006 / Skin permeation of different steroid hormones from polymeric coated liposomal formulations / Eur. J. Pharm. Biopharm 62:210~219
Burnette, R. R / 1987 / Characterization of the permselective properties of excised human skin during iontophoresis / J. Pharm. Sci 76:765~773
Balakrishnan, P / 2009 / Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery / INTERNATIONAL JOURNAL OF PHARMACEUTICS 377:1~8
Biruss, B / 2007 / The infl uence of selected steroid hormones on the physicochemical behavior of DPPC liposomes / Chem. Phys. Lipids 148:84~90
Biruss, B / 2006 / Skin permeation of different steroid hormones from polymeric coated liposomal formulations / Eur. J. Pharm. Biopharm 62:210~219
Burnette, R. R / 1987 / Characterization of the permselective properties of excised human skin during iontophoresis / J. Pharm. Sci 76:765~773
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