Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone

Lim, Hee-Na; Jang, So-Yong; Lee, Yeon-Ju; Moon, So-Hyeon; Kim, Ji-Eun; Oh, Sei-Kwan

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자료유형: 학술저널

저자정보: Lim, Hee-Na (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University) Jang, So-Yong (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University) Lee, Yeon-Ju (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University) Moon, So-Hyeon (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University) Kim, Ji-Eun (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University) Oh, Sei-Kwan (Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제20권 제4호

발행연도: 2012.1

수록면: 418 - 424 (7page)

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Repeated stress induces corticosterone release. However, it is not clear that stress results in further elevation of corticosterone levels, and the roles of released corticosterone to aggravate stress-related symptoms are also not clear. This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. It was found that stress by electric shock decreased the expression of tyrosine hydoroxylase (TH) in the amygdala while the expression of pERK was increased. However, there is no difference in the expressions of TH and pERK in the frontal cortex compared with those of the control group. The level of corticosterone was significantly increased in the serum after stress. To determine the effect of corticosterone on the induction of anxiety and the expression of TH, the rats received corticosterone (20 mg or 40 mg/kg i.p.) for 1 day, 1 week, 2 weeks and 3 weeks, respectively. The spent time in open arms of the EPM (elevated plus maze) test was significantly decreased after 1 week, 2 weeks and 3 weeks. The time spent in open arms of the EPM test after repeated injections of corticosterone was significantly decreased in a dose-dependent manner. The expression of TH in the amygdala was reduced after following repeated corticosterone treatment for 2 weeks and 3 weeks. Collectively, this study suggests that corticosterone has a major role in the induction of anxiety and the modulation of TH expression, at least, in the amygdala.

#Amygdala #Stress #Anxiety #Corticosterone #TH

참고문헌 (44)

참고문헌 신청

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