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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 201 - 205 (5page)
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초록· 키워드
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Although various biological activities of resveratrol have been extensively studied, most reports have focused on trans-resveratrol and little attention has been paid to the cis-isomer. In this study, the effect of cis-resveratrol on platelet activity was examined and compared with that of the trans-isomer. Treatment with cis-resveratrol resulted in inhibition of platelet aggregation induced by thrombin, collagen or ADP, which are representative aggregation-inducing agents, and the trans-isomer elicited the same effects. These effects were concentration-dependent in the range of 1-100 ${\mu}M$. However, the potency of the cis-isomer was much lower than that of the trans-isomer; the $IC_{50}$ values for the cis-isomer versus the trans-isomer were $31{\pm}12$ vs $151{\pm}3$, $161{\pm}3$ vs $91{\pm}4$, and $601{\pm}15$ vs $251{\pm}6\;{\mu}M$ for thrombin-, collagen- and ADP-induced aggregation, respectively. These results indicate that cis-resveratrol has a less potent anti-platelet activity, compared with the trans-isomer, and raise the possibility that the biological activities of the cis-isomer may be different from those of the trans-isomer. It will be necessary to evaluate the activity of cis-resveratrol independently of the trans-isomer.
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참고문헌 (28)
참고문헌 신청
Aumont, V / 2001 / Regioselective and stereospecifi c glucuronidation of trans- and cis-resveratrol in human / Arch. Biochem. Biophys 393:281~289
Bertelli, A. A / 1996 / Antiplatelet activity of cis-resveratrol / Drugs Exp. Clin. Res 22:61~63
Campos-Toimil, M / 2007 / Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes / Eur. J. Pharmacol 577:91~99
Campos-Toimil, M / 2005 / Trans- and cisresveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells / Mol. Nutr. Food Res 49:396~404
Crescente, M / 2009 / Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level Functional and modelling studies / Thromb. Haemostasis 102:336~346
Bertelli, A. A / 1996 / Antiplatelet activity of cis-resveratrol / Drugs Exp. Clin. Res 22:61~63
Campos-Toimil, M / 2007 / Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes / Eur. J. Pharmacol 577:91~99
Campos-Toimil, M / 2005 / Trans- and cisresveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells / Mol. Nutr. Food Res 49:396~404
Crescente, M / 2009 / Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level Functional and modelling studies / Thromb. Haemostasis 102:336~346
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