지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 181 - 189 (9page)
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초록· 키워드
오류제보하기
Motilitone$^{(R)}$ (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profile of DA-9701 is also preferable to that of other treatments.
목차
등록된 정보가 없습니다.
참고문헌 (116)
참고문헌 신청
Adsersen, A. / 2007 / Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort / J. Ethnopharmacol 113:179~182
Agreus, L. / 1995 / Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time / Gastroenterology 109:671~680
Al-Chaer, E. D. / 2000 / A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development / Gastroenterology 119:1276~1285
Azpiroz, F. / 1985 / Physiological variations in canine gastric tone measured by an electronic barostat / Am. J. Physiol 248:229~237
Azpiroz, F. / 1986 / Vagally mediated gastric relaxation induced by intestinal nutrients in the dog / Am. J. Physiol 251:727~735
Agreus, L. / 1995 / Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time / Gastroenterology 109:671~680
Al-Chaer, E. D. / 2000 / A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development / Gastroenterology 119:1276~1285
Azpiroz, F. / 1985 / Physiological variations in canine gastric tone measured by an electronic barostat / Am. J. Physiol 248:229~237
Azpiroz, F. / 1986 / Vagally mediated gastric relaxation induced by intestinal nutrients in the dog / Am. J. Physiol 251:727~735
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