지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 226 - 233 (8page)
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초록· 키워드
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Ethanol exposure during gestational period is related to growth retardation, morphological abnormality, and even in neurological abnormalities including attention deficit/hyperactivity disorder (ADHD)-like behaviors on offspring. However, relatively little is known about the effects of maternal ethanol consumption prior to conception on their offspring. In this study, we investigated whether maternal ethanol administration during preconceptional phase produces ADHD-like behaviors in the rat offspring. Sprague-Dawley (SD) female rats were administrated ethanol via intragastric intubation with dosing regimen of 6 g/kg daily for 10 consecutive days and treated female rats then mated with non-treated male SD rats after 8 weeks. Another group subjected to the same procedure as those conducted on ethanol treated group except the saline administration instead of ethanol. Offspring was tested for their ADHD-like behaviors using open field test, Y maze test and impulsivity test that is performed in the aversive electronic foot shock paradigm. Offspring of preconceptional ethanol treated (EtOH) group showed hyperlocomotive activity, attention deficit and impulsivity. And reduction of striatal dopamine transporter (DAT) level was observed by Western blot in the EtOH group, compared to control (Con) group, while the immunohistochemical analysis exhibited increased expression of norepinephrine transporter (NET) in the frontal cortex. These results suggest that maternal ethanol consumption in the preconceptional phase induces ADHD-like behaviors in offspring that might be related to the abnormal expression of DAT and NET in rat.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Abel, E. L. / 1994 / Effects of physostigmine on male offspring sired by alcohol-treated fathers / Alcohol. Clin. Exp. Res 18:648~652
American Psychiatric Association / 1994 / Diagnostic and statistical manual of mental disorder. (4th Ed.) / American Psychiatry Press
Barkley, R. A. / 1990 / Attention-defi cit hyperactivity disorder: A handbook for diagnosis and treatment / Guilford Press
Barr, C. L. / 2002 / The norepinephrine transporter gene and attention-defi cit hyperactivity disorder / Am. J. Med. Genet 114:255~259
Biederman, J. / 2005 / Absence of gender effects on attention defi cit hyperactivity disorder: fi ndings in nonreferred subjects / Am. J. Psychiatry 162:1083~1089
American Psychiatric Association / 1994 / Diagnostic and statistical manual of mental disorder. (4th Ed.) / American Psychiatry Press
Barkley, R. A. / 1990 / Attention-defi cit hyperactivity disorder: A handbook for diagnosis and treatment / Guilford Press
Barr, C. L. / 2002 / The norepinephrine transporter gene and attention-defi cit hyperactivity disorder / Am. J. Med. Genet 114:255~259
Biederman, J. / 2005 / Absence of gender effects on attention defi cit hyperactivity disorder: fi ndings in nonreferred subjects / Am. J. Psychiatry 162:1083~1089
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