지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 482 - 486 (5page)
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초록· 키워드
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Cerebral monoamines play important roles as neurotransmitters that are associated with various stressful stimuli. Some components such as ginsenosides (triterpenoidal glycosides derived from the Ginseng Radix) may interact with monoamine systems. The aim of this study was to determine whether ginsenoside Rb1 can modulate levels of the monoamines such as dihydroxyphenylalanine (DOPA), dopamine (DA), norepinephrine (NE), epinephrine (EP), 3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydorxytryptamine (5-HT), 5-hydroxindole-3-acetic acid (5-HIAA), and 5-hydroxytryptophan (5-HTP) in mice frontal cortex and cerebellum in response to immobilization stress. Mice were treated with ginsenoside Rb1 (10 mg/kg, oral) before a single 30 min immobilization stress. Acute immobilization stress resulted in elevation of monoamine levels in frontal cortex and cerebellum. Pretreatment with ginsenoside Rb1 attenuated the stress-induced changes in the levels of monoamines in each region. The present findings showed the anti-stress potential of ginsenoside Rb1 in relation to regulation effects on the cerebral monoaminergic systems. Therefore, the ginsenoside Rb1 may be a useful candidate for treating several brain symptoms related with stress.
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참고문헌 (23)
참고문헌 신청
Bhattacharyya, D / 1999 / The effect of panax ginseng and diazepam on norepinephrine levels of whole brain and hypothalamus during stress / Indian. J. Pharmacol 31:124~127
Byun, J. A. / 2008 / Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography–tandem mass spectrometry / Biomed. Chromatogr 22:73~80
Cikos, S. / 2011 / Biogenic monoamines in preimplantation development / Hum. Reprod 26:2296~2305
Dunn, A. J. / 1998 / Stress-related activation of cerebral dopaminergic systems / Ann. N. Y. Acad. Sci 537:188~205
Feldman, S. / 1995 / Limbic pathways and hypothalamic neurotransmitters mediating adrenocortical responses to neural stimuli / Neurosci. Biobehav. Rev 19:235~240
Byun, J. A. / 2008 / Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography–tandem mass spectrometry / Biomed. Chromatogr 22:73~80
Cikos, S. / 2011 / Biogenic monoamines in preimplantation development / Hum. Reprod 26:2296~2305
Dunn, A. J. / 1998 / Stress-related activation of cerebral dopaminergic systems / Ann. N. Y. Acad. Sci 537:188~205
Feldman, S. / 1995 / Limbic pathways and hypothalamic neurotransmitters mediating adrenocortical responses to neural stimuli / Neurosci. Biobehav. Rev 19:235~240
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