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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 177 - 182 (6page)
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Tetrazolium violet is a tetrazolium salt and has been proposed as an antitumor agent. In this study, we reported for the first time that tetrazolium violet not only inhibited human lung cancer A549 cell proliferation but also induced apoptosis and blocked cell cycle progression in the G1 phase. The results showed that tetrazolium violet significantly decreased the viability of A549 cells at $5-15{\mu}M$. Tetrazolium violet -induced apoptosis in A549 cells was confirmed by H33258 staining assay. In A549, tetrazolium violet blocked the progression of the cell cycle at G1 phase by inducing p53 expression and further up-regulating p21/WAF1 expression. In addition, an enhancement in Fas/APO-1 and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), as well as caspase, were responsible for the apoptotic effect induced by tetrazolium violet. The conclusion of this study is that tetrazolium violet induced p53 expression which caused cell cycle arrest and apoptosis. These findings suggest that tetrazolium violet has strong potential for development as an agent for treatment lung cancer.
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참고문헌 (35)
참고문헌 신청
Brown, J. M. / 1999 / Apoptosis, p53, and tumor cell sensitivity to anticancer agents / Cancer Res 59:1391~1399
Brüne, B. / 2005 / The intimate relation between nitric oxide and superoxide in apoptosis and cell survival / Antioxid. Redox. Signal 7:497~507
Cheng-fa Cai / 2009 / Tetrazolium Violet Induces Apoptosis via Caspases-8, -9 Activation and Fas/FasL Up-regulation in Rat C6 Glioma Cells / Archives of Pharmacal Research 32(4):575~581
Castañeda, F. / 2001 / Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway / J. Cancer Res. Clin. Oncol 127:418~424
Chang, J. S. / 2004 / Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line / Clin. Exp. Pharmacol. Physiol 31:716~722
Brüne, B. / 2005 / The intimate relation between nitric oxide and superoxide in apoptosis and cell survival / Antioxid. Redox. Signal 7:497~507
Cheng-fa Cai / 2009 / Tetrazolium Violet Induces Apoptosis via Caspases-8, -9 Activation and Fas/FasL Up-regulation in Rat C6 Glioma Cells / Archives of Pharmacal Research 32(4):575~581
Castañeda, F. / 2001 / Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway / J. Cancer Res. Clin. Oncol 127:418~424
Chang, J. S. / 2004 / Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line / Clin. Exp. Pharmacol. Physiol 31:716~722
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