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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 243 - 247 (5page)
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초록· 키워드
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Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were significantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also significantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
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참고문헌 (22)
참고문헌 신청
Bechtel, Y. C / 1993 / A population and family study of N-acetyltransferase using caffeine urinary metabolites / Clin. Pharmacol. Ther 54:134~141
Sudeep R. Bista / 2008 / Effects of Oral Rutaecarpine on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats / 한국독성학회지 24(3):195~199
Caubet, M. S / 2004 / Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity / J. Pharmaceut. Biomed. Anal 34:379~389
Chen, L / 1996 / Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats / Drug Metab. Dispos 24:529~533
Chiou, W. F / 1996 / Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa / J. Nat. Prod 59:374~378
Sudeep R. Bista / 2008 / Effects of Oral Rutaecarpine on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats / 한국독성학회지 24(3):195~199
Caubet, M. S / 2004 / Determination of urinary 13C-caffeine metabolites by liquid chromatography-mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity / J. Pharmaceut. Biomed. Anal 34:379~389
Chen, L / 1996 / Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats / Drug Metab. Dispos 24:529~533
Chiou, W. F / 1996 / Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa / J. Nat. Prod 59:374~378
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