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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 224 - 230 (7page)
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초록· 키워드
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In order to develop silk peptide (SP) preparations possessing cognition-enhancing effect, several candidates were screened through in vitro assays, and their effectiveness was investigated in facilitated brain aging model rats. Incubation of brain acetyl-cholinesterase with SP-PN (1-1,000 ${\mu}g/ml$) led to inhibition of the enzyme activity up to 35%, in contrast to a negligible effect of SP-NN. The expression of choline acetyltransferase (ChAT) mRNA of neural stem cells expressing ChAT gene (F3.ChAT) was increased by 24-hour treatment with 10 and 100 ${\mu}g/ml$ SP-NN (1.35 and 2.20 folds) and SP-PN (2.40 and 1.34 folds). Four-week subcutaneous injections with D-galactose (150 mg/kg) increased activated hippocampal astrocytes to 1.7 folds (a marker of brain injury and aging), decreased acetylcholine concentration in cerebrospinal fluid by 45-50%, and thereby impaired learning and memory function in passive avoidance and water-maze performances. Oral treatment with SP preparations (50 or 300 mg/kg) for 5 weeks from 1 week prior to D-galactose injection exerted recovering activities on acetylcholine depletion and brain injury/aging as well as cognitive deficit induced by D-galactose. The results indicate that SP preparations restore cognitive functions of facilitated brain aging model rats by increasing the release of acetylcholine, in addition to neuroprotective activity.
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참고문헌 (48)
참고문헌 신청
Abe, E / 1993 / α-Sialyl cholesterol reverses AF64A-induced defi cit in passive avoidance response and depletion of hippocampal acetylcholine in mice / Br. J. Pharmacol 108:387~392
Barnes, C. A / 1979 / Memory defi cits associated with senescence: a neurophysiological and behavioral study in the rat / J. Comp. Physiol. Psychol 93:74~104
Bessho, T / 2008 / MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats / J. Neural Transm 115:1019~1025
Chen, C. / 2008 / Treatment with dehydroepiandrosterone increases peripheral benzodiazepine receptors of mitochondria from cerebral cortex in D-galactose-induced aged rats / Basic Clin. Pharmacol. Toxicol 103:493~501
Coyle, J. T / 1983 / Alzheimer’s disease: a disorder of cortical cholinergic innervation / Science 219:1184~1190
Barnes, C. A / 1979 / Memory defi cits associated with senescence: a neurophysiological and behavioral study in the rat / J. Comp. Physiol. Psychol 93:74~104
Bessho, T / 2008 / MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats / J. Neural Transm 115:1019~1025
Chen, C. / 2008 / Treatment with dehydroepiandrosterone increases peripheral benzodiazepine receptors of mitochondria from cerebral cortex in D-galactose-induced aged rats / Basic Clin. Pharmacol. Toxicol 103:493~501
Coyle, J. T / 1983 / Alzheimer’s disease: a disorder of cortical cholinergic innervation / Science 219:1184~1190
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