지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 77 - 83 (7page)
이용수
초록· 키워드
오류제보하기
Sulforaphane is an isothiocyanate found in cruciferous vegetables that has been reported to be an effective cancer preventive agent inducing growth arrest and/or cell death in cancer cells of various organs. This paper reports that sulforaphane exerts immunomodulatory activity on the MHC-restricted antigen presenting function. Sulforaphane efficiently increased the class II-restricted presentation of an exogenous antigen, ovalbumin (OVA), in both dendritic cells (DCs) and peritoneal macrophages in vitro. The class II-restricted OVA presentation-enhancing activity of sulforaphane was also confirmed using mice that had been injected with sulforaphane followed by soluble OVA. On the other hand, sulforaphane did not affect the class I-restricted presentation of exogenous OVA at concentrations that increase the class II-restricted antigen presentation. At a high concentration ($20\;{\mu}M$), sulforaphane inhibited the class I-restricted presentation of exogenous OVA. Sulforaphane did not affect the phagocytic activity of the DCs, and the cell surface expression of total H-$2K^b$, B7-1, B7-2 and CD54 molecules, even though it increased the expression of I-$A^b$ molecules to a barely discernable level. These results show that sulforaphane increases the class II-restricted antigen presenting function preferentially, and might provide a novel insight into the mechanisms of the anti-cancer effects of sulforaphane.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Ambrosone, C. B / 2004 / Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modifi ed by GST genotype / J. Nutr 134:1134~1138
Bevan, M. J / 1976 / Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not crossreact in the cytotoxic assay / J. Immunol 185:1361~1366
Bones, A. M / 2006 / The enzymic and chemically induced decomposition of glucosinolates / Phytochemistry 67:1053~1067
Fimognari, C / 2007 / Sulforaphane as a promising molecule for fi ghting cancer / Mutat. Res 635:90~104
Gamet-Payrastre, L / 2000 / Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells / Cancer Res 60:1426~1433
Bevan, M. J / 1976 / Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not crossreact in the cytotoxic assay / J. Immunol 185:1361~1366
Bones, A. M / 2006 / The enzymic and chemically induced decomposition of glucosinolates / Phytochemistry 67:1053~1067
Fimognari, C / 2007 / Sulforaphane as a promising molecule for fi ghting cancer / Mutat. Res 635:90~104
Gamet-Payrastre, L / 2000 / Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells / Cancer Res 60:1426~1433
이 논문의 저자 정보
최근 본 자료
댓글(0)
0