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자료유형
학술저널
저자정보
Hong, Ji-Young (College of Pharmacy, Ewha Womans University) Song, Su-Hyun (College of Pharmacy, Ewha Womans University) Park, Hyen-Joo (College of Pharmacy, Ewha Womans University) Cho, Yong-Jin (Food Nano-Biotechnology Research Center, Korea Food Research Institute) Pyee, Jae-Ho (College of Natural Sciences, Dankook University) Lee, Sang-Kook (College of Pharmacy, Ewha Womans University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제16권 제3호
발행연도
2008.1
수록면
286 - 292 (7page)

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Strawberry is widely consumed in diet and has been attracted much attention due to its potential for human health benefits. Strawberry contains a diverse range of phytochemicals but the biological activities with molecular mechanisms are poorly elucidated yet. In this study, the effects of the extracts of strawberry (Maehyang cultivar) on antioxidant, antiinflammatory, and antiproliferative potential against various cancer cells were investigated. The strawberry extracts (SE) of Maehyang cultivar showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activities. In addition, SE inhibited the growth of human colon (HCT-116), lung (A549), stomach (SNU-638) and fibrosarcoma (HT-1080) cancer cells. The strawberry extracts also exhibited the inhibitory effect on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and suppressed LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in mouse macrophage RAW 264.7 cells. These findings suggest that the strawberry extracts (Maehyang cultivar) might have antioxidant, antiinflammotry, and anticancer activities.

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