지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 34 - 39 (6page)
이용수
초록· 키워드
오류제보하기
Oxidative stress may represent a common link between chronic liver damage and hepatic fibrosis. In the present study, we investigated activity changes of sphingomyelin catabolic enzymes, such as sphingomyelinases and ceramidases by using dimethylnitrosamine (DMN)-treated Sprague-Dawley (SD) male rats hepatic fibrosis model as a hepatic fibrosis model. Twenty rats divided into five groups received: (1) saline; (2) DMN for 1 week, (3) DMN for 2 weeks, (4) DMN for 3 weeks, and (5) DMN for 4 weeks by intraperitoneally 10 mg/kg of body weight for three consecutive days a week. Activities of acidic and neutral sphingomyelinases and acidic, neutral and alkaline ceramidases were measured in the liver and kidney from DMN-treated rats. We found increased ceramidase activities from 2-week and/or 3-week DMN treated rat livers compared to control rat liver. Acidic sphingomyelinase and alkaline ceramidase activities were significantly increased in 3-week DMN-treated rat kidneys compared to control rat kidney. Therefore, sphingolipid metabolizing enzymes and sphingolipid metabolites are supposed to be involved in liver fibrosis, although further investigation is necessary to elucidate meanings of sphingolipids during the liver fibrosis
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Chalfant, C. E / 2002 / De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1 / J Biol Chem 277:12587~12595
Chen, J / 1995 / gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes / J Biol Chem 270:25233~25238
Chun, Y. J / 2003 / Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells / Toxicol Lett 146:75~81
Cock, J. G / 1998 / CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase / J Biol Chem 273:7560~7565
Cuvillier, O / 2003 / Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer / Pharmacol Res 47:439~445
Chen, J / 1995 / gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes / J Biol Chem 270:25233~25238
Chun, Y. J / 2003 / Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells / Toxicol Lett 146:75~81
Cock, J. G / 1998 / CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase / J Biol Chem 273:7560~7565
Cuvillier, O / 2003 / Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer / Pharmacol Res 47:439~445
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Activity Change of Sphingomyelin Anabolic Enzymes during Dimethylnitrosamine-induced Hepatic Fibrosis in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
Effects of HepacureⓇ on Dmn Induced Hepatic Fibrosis in Rat
한국실험동물학회 학술발표대회 논문집
2004 .06
-
Naringenin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats
대한약학회 학술대회
2003 .01
-
茵蔯淸肝湯이 DMN에 의한 간손상 proteome에 미치는 영향
대한한방내과학회지
2007 .01
-
천연식물추출물(RIP)이 쥐의 간섬유화 치료에 미치는 영향
기초간호자연과학회지
2006 .01
-
The Flavonoid Morin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats
대한약학회 학술대회
2003 .01
-
DMN으로 유발된 흰쥐의 간섬유화에 미치는 大薊의 효과
동의생리병리학회지
2004 .04
-
Effects of Platycodi Radix on dimethylnitrosamine-induced hepatic fibrosis in rats
대한약학회 학술대회
2002 .01
-
Effect of Resveratrol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats
대한약학회 학술대회
2001 .01
-
Dimethylnitrosamine 유발 급성 간 손상 흰쥐에서 $^{99m}-Lactosylated$ Serum Albumin을 이용한 간 기능의 평가
대한핵의학회지
2003 .01
-
DMN 유발 간경변증에서 간세포 및 간 성상세포의 세포주기 조절 단백질 발현 양상
Laboratory Animal Research
2003 .09
-
茵蔯淸肝湯이 DMN 유발 간섬유화와 단백질 발현에 미치는 영향
대한한방내과학회지
2008 .01
-
Aspirin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats
대한약학회 학술대회
2003 .01
-
실험적 간경화 동물모델 비교
약학회지
1997 .01
-
Effect of skin and seed of Grape and on Dimethylnitrosamine-Induced Liver Damage in Rats
대한약학회 학술대회
2003 .01
-
Effect of Proanthocyanidins on Dimethylnitrosamine-Induced Liver Damage in Rats
대한약학회 학술대회
2003 .01
-
사염화탄소 투여가 Dimethylnitrosamine의 급성중독 간세포의 구조에 미치는 영향
영남의대학술지
1991 .01
-
Effect of Solanum Iyratum Extract on Dimethylnitrosamine-Induced Liver Damage in Rats
대한약학회 학술대회
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0