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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 38 - 47 (10page)
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Research into new methods for identifying highly expressed genes in anonymous genome sequences has been going on for more than 15 years. We presented here an alternative approach based on modified score of relative codon usage bias to identify highly expressed genes in crenarchaeal genomes. The proposed algorithm relies exclusively on sequence features for identifying the highly expressed genes. In this study, a comparative analysis of predicted highly expressed genes in five crenarchaeal genomes was performed using the score of Modified Relative Codon Bias Strength (MRCBS) as a numerical estimator of gene expression level. We found a systematic strong correlation between Codon Adaptation Index and MRCBS. Additionally, MRCBS correlated well with other expression measures. Our study indicates that MRCBS can consistently capture the highly expressed genes.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Gustafsson C / 2004 / Codon bias and heterologous protein expression / Trends Biotechnol 22:346~353
Kurland CG / 1993 / Major codon preference: theme and variations / Biochem Soc Trans 21:841~846
Sharp PM / 1993 / Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure / Nucleic Acids Res 21:179~183
Akashi H / 1994 / Synonymous codon usage in Drosophila melanogaster:natural selection and translational accuracy / Genetics 136:927~935
Baker SF / 2015 / Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines / Future Virol 10:715~730
Kurland CG / 1993 / Major codon preference: theme and variations / Biochem Soc Trans 21:841~846
Sharp PM / 1993 / Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure / Nucleic Acids Res 21:179~183
Akashi H / 1994 / Synonymous codon usage in Drosophila melanogaster:natural selection and translational accuracy / Genetics 136:927~935
Baker SF / 2015 / Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines / Future Virol 10:715~730
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