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논문 기본 정보

자료유형
학술저널
저자정보
Im, Chang-Nim (Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences) Kim, Byeong Mo (Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences) Moon, Eun-Yi (Department of Bioscience and Biotechnology, Sejong University) Hong, Da-Won (Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences) Park, Joung Whan (Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences) Hong, Sung Hee (Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences)
저널정보
한국유전체학회 Genomics & informatics Genomics & informatics 제11권 제4호
발행연도
2013.1
수록면
245 - 253 (9page)

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A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.
#apoptosis #lung neoplasms #matrix metalloproteinases #radioresistance #syntrophin beta 2

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참고문헌 (32)

참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 / Int J Cancer 127:2893~2917 google schola Zarogoulidis K / 2013 / Treatment of non-small cell lung cancer (NSCLC) / J Thorac Dis 5(Suppl 4):S389~S396 google schola Baumann M / 2008 / Exploring the role of cancer stem cells in radioresistance / Nat Rev Cancer 8:545~554 google schola Camphausen K / 2001 / Radiation therapy to a primary tumor accelerates metastatic growth in mice / Cancer Res 61:2207~2211 google schola Cheng JC / 2006 / Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway / Oncogene 25:7009~7018 google schola

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