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자료유형
학술저널
저자정보
Yavartanoo, Maryam (Department of Bio and Brain Engineering, KAIST) Choi, Jung Kyoon (Department of Bio and Brain Engineering, KAIST)
저널정보
한국유전체학회 Genomics & informatics Genomics & informatics 제11권 제1호
발행연도
2013.1
수록면
2 - 6 (5page)

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Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Research Institute (NHGRI) launched an international research consortium called Encyclopedia of DNA Elements (ENCODE) to uncover non-coding functional elements in the human genome. The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. The project gives us new insights into the organization and regulation of the human genome and epigenome. Here, we sought to summarize particular aspects of the ENCODE project and highlight the features and data that have recently been released. At the end of this review, we have summarized a case study we conducted using the ENCODE epigenome data.

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