지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 283 - 288 (6page)
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Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. But, there is still a gap in deciding on the choice of a drug, especially when the target is mutated. Mutations in the KCNJ11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 diabetes, and due to the lack of its 3D structure, an attempt has been made to predict the structure of kir6.2, applying fold recognition methods. The current work is intended to investigate the affinity of four phytochemicals namely, curcumin (Curcuma longa), genistein (Genista tinctoria), piperine (Piper nigrum), and pterostilbene (Vitis vinifera) in a normal as well as in a mutant kir6.2 model by adopting a molecular docking methodology. The phytochemicals were docked in both wild and mutated kir6.2 models in two rounds: blind docking followed by ATP-binding pocket-specific docking. From the binding pockets, the common interacting amino acid residues participating strongly within the binding pocket were identified and compared. From the study, we conclude that these phytochemicals have strong affinity in both the normal and mutant kir6.2 model. This work would be helpful for further study of the phytochemicals above for the treatment of type 1 diabetes by targeting the kir6.2 channel.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Notkins AL / 2002 / Immunologic and genetic factors in type 1diabetes / J Biol Chem 277:43545~43548
Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation / Diabet Med 15:539~553
Gupta R / 2007 / An overview of Indian novel traditional medicinal plants with anti-diabetic potentials / Afr J Tradit Complement Altern Med 5:1~17
Kuhad A / 2007 / Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences / Eur J Pharmacol 576:34~42
Choi MS / 2008 / Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice / Diabetes Metab Res Rev 24:74~81
Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation / Diabet Med 15:539~553
Gupta R / 2007 / An overview of Indian novel traditional medicinal plants with anti-diabetic potentials / Afr J Tradit Complement Altern Med 5:1~17
Kuhad A / 2007 / Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences / Eur J Pharmacol 576:34~42
Choi MS / 2008 / Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice / Diabetes Metab Res Rev 24:74~81
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