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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 12 - 20 (9page)
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The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression.
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참고문헌 (93)
참고문헌 신청
Kalluri R / 2009 / EMT: when epithelial cells decide to become mesenchymal-like cells / J Clin Invest 119:1417~1419
Thiery JP / 2009 / Epithelial-mesenchymal transitions in development and disease / Cell 139:871~890
Thiery JP / 2006 / Complex networks orchestrate epithelial-mesenchymal transitions / Nat Rev Mol Cell Biol 7:131~142
Yang J / 2008 / Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis / Dev Cell 14:818~829
Peinado H / 2007 / Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? / Nat Rev Cancer 7:415~428
Thiery JP / 2009 / Epithelial-mesenchymal transitions in development and disease / Cell 139:871~890
Thiery JP / 2006 / Complex networks orchestrate epithelial-mesenchymal transitions / Nat Rev Mol Cell Biol 7:131~142
Yang J / 2008 / Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis / Dev Cell 14:818~829
Peinado H / 2007 / Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? / Nat Rev Cancer 7:415~428
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