Properties of Synchronous Versus Metachronous Bilateral Breast Carcinoma with Long Time Follow Up

Eliyatkin, Nuket; Zengel, Baha; Yagci, Ayse; Comut, Erdem; Postaci, Hakan; Uslu, Adam; Aktas, Safiye

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자료유형: 학술저널

저자정보: Eliyatkin, Nuket (Pathology, Faculty of Medicine, Adnan Menderes University) Zengel, Baha (General Surgery, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) Yagci, Ayse (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) Comut, Erdem (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) Postaci, Hakan (Pathology, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) Uslu, Adam (General Surgery, Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital) Aktas, Safiye (Basic Oncology Institute of Oncology, Dokuz Eylul University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 4,921 - 4,926 (6page)

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Background: Breast cancer is the most common cancer type among women with increasing incidence rates, improved prognosis and survival. According to the localization of the tumor, breast cancer is designated as unilateral (UBC) or bilateral (BBC). BBC can be classified as synchronous (SBBC) or metachronous (MBBC) based on the time interval between the diagnosis of the first and the secondary tumors. According to the guideline of WHO 2012, BBC is generally defined as SBBC when contralateral breast carcinoma is diagnosed within 3 months. The aim of this study was to compare the characteristics and patterns of metastasis of BBC patients with UBC. Materials and Methods: A cohort of 768 patients with breast cancer treated at the Turkish Ministry of Health-Izmir Bozyaka Research and Training Hospital between 1976 and 2012 were studied. Survival analysis was performed comparing UBC and BBC patients. In addition, evaluations were performed in patients with SBBC and MBBC sub-groups. We used a 3-months interval to distinguish metachronous from synchronous. Results: When clinical and histopathological parameters were statistically evaluated, ER status, event-free and overall survival were found to be significant between UBC and BBC patients. In comparison of SBBC and MBBC patients, age, histological type of tumor, event-free and overall survival were found to be significant. Conclusions: BBC cases were found to show worse prognosis than UBC cases. Among BBC, SBBC had the worst prognosis based on overall survival rates.

#Bilateral breast cancer #unilateral breast cancer #metachronous #synchronous

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