Association of DR4 (TRAIL-R1) Polymorphisms with Cancer Risk in Caucasians: an Updated Meta-analysis

Chen, Wei; Tang, Wen-Ru; Zhang, Ming; Chang, Kwenjen; Wei, Yun-Lin

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자료유형: 학술저널

저자정보: Chen, Wei (Faculty of Medicine, Kunming University of Science and Technology) Tang, Wen-Ru (Faculty of Medicine, Kunming University of Science and Technology) Zhang, Ming (Faculty of Life Science and Technology, Kunming University of Science and Technology) Chang, Kwenjen (Faculty of Life Science and Technology, Kunming University of Science and Technology) Wei, Yun-Lin (Faculty of Life Science and Technology, Kunming University of Science and Technology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제6호

발행연도: 2014.1

수록면: 2,889 - 2,892 (4page)

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Death receptor 4 (TRAIL-R1 or DR4) polymorphisms have been associated with cancer risk, but findings have been inconsistent. To estimate the relationship in detail, a meta-analysis was here performed. A search of PubMed was conducted to investigate the association between DR4 C626G, A683C and A1322G polymorphisms and cancer risk, using odds ratios (ORs) with 95% confidence intervals. The results suggested that DR4 C626G and A683C polymorphisms were indeed associated with cancer risk (for C626G, dominant model, OR 0.991, 95%CI 0.866-1.133, p=0.015; for A683C, additive model, OR=1.140, 95%CI: 0.948-1.370, p=0.028; dominant model, OR=1.156, 95%CI: 0.950-1.406, p=0.080) in the Caucasian subgroup. However, the association was not significant between DR4 polymorphism A1322G with cancer risk in Caucasians (For A1322G, additive model: OR 1.085, 95%CI 0.931-1.289, p=0.217; dominant model: OR 1.379, 95%CI 0.934-2.035, p=0.311; recessive model: OR 1.026, 95%CI 0.831-1.268 p=0.429.). In summary, our finding suggests that DR4 polymorphism C626G and A683 rather than A1322G are associated with cancer risk in Caucasians.

#Death receptor 4 #DR4) #polymorphism #Caucasians #cancer risk

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Chen, Wei

소속기관 Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University