Are Bladder Neoplasms More Aggresive in Patients with a Smoking-related Second Malignancy?

Otunctemur, Alper; Koklu, Ismail; Ozbek, Emin; Dursun, Murat; Sahin, Suleyman; Besiroglu, Huseyin; Erkoc, Mustafa; Danis, Eyyup; Bozkurt, Muammer; Gurbuz, Ahmet

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자료유형: 학술저널

저자정보: Otunctemur, Alper (Department of Urology, Okmeydani Training and Research Hospital) Koklu, Ismail (Department of Urology, Okmeydani Training and Research Hospital) Ozbek, Emin (Department of Urology, Ataturk Training and Research Hospital, Katip Celebi University) Dursun, Murat (Department of Urology, Bahcelievler State Hospital) Sahin, Suleyman (Department of Urology, Okmeydani Training and Research Hospital) Besiroglu, Huseyin (Department of Urology, Okmeydani Training and Research Hospital) Erkoc, Mustafa (Department of Urology, Okmeydani Training and Research Hospital) Danis, Eyyup (Department of Urology, Okmeydani Training and Research Hospital) Bozkurt, Muammer (Department of Urology, Okmeydani Training and Research Hospital) Gurbuz, Ahmet (Department of Urology, Okmeydani Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 4,025 - 4,028 (4page)

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Background: Relationships between smoking and bladder neoplasms, one of the common malignancies, are well-known. Different smoking-related malignancies may occur together. In this study, we evaluated the stage and grade of bladder neoplasms in patients also featuring lung or larynx cancer. Materials and Methods: From January 2006 to February 2012, patients who underwent surgery for bladder neoplasms in our clinic were screened retrospectively. In the evaluation, 5 patients had larynx cancer and 20 patients have lung cancer in addition, all having been smoking for a long time. The bladder tumor stage and grade were investigated in these 25 cases. Results: Mean age of patients was 66.8 (49-78). In the evaulation, all of 5 patients who had larnyx cancer also had high grade urothelial cancer. One had T2 urothelial, and 3 T1 urothelial cancer. In the same way, all of the 20 patients with lung cancer also have high grade urothelial cancer, three T2, and 13 T1. Bladder cancer stage and grade were determined to be significantly increased in patients with concomitant bladder and lung or larynx cancer. Conclusions: In the patients who have smoking releated second malignancy, bladder cancer prognosis appears more aggressive. We now need a larger series and multi-center studies for understanding relevant pathophysiology.

#Bladder neoplasm #lung cancer #larynx cancer #concomitant lesions #smoking #prognosis

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