Performance of Siriraj Liquid-Based Cytology: a Single Center Report Concerning over 100,000 Samples

Sangkarat, Suthi; Laiwejpithaya, Somsak; Rattanachaiyanont, Manee; Chaopotong, Pattama; Benjapibal, Mongkol; Wongtiraporn, Weerasak; Laiwejpithaya, Sujera

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자료유형: 학술저널

저자정보: Sangkarat, Suthi (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Laiwejpithaya, Somsak (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Rattanachaiyanont, Manee (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Chaopotong, Pattama (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Benjapibal, Mongkol (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Wongtiraporn, Weerasak (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University) Laiwejpithaya, Sujera (Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제5호

발행연도: 2014.1

수록면: 2,051 - 2,055 (5page)

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Background: To evaluate the performance of Siriraj liquid-based cytology (LBC) for cervical neoplasia screening after increasing use of this technology. Materials and Methods: Cytological reports of 103,057 Siriraj-LBC specimens obtained in 2007-2009 were compared with those of 23,676 specimens obtained in 2006. Results: Comparing with the year 2006, the 2007-2009 patients were slightly older ($43.4{\pm}12.yr$ vs $42.7{\pm}12.2yr$, p <0.001), and their specimens had much lower proportion of unsatisfactory slides (OR=0.06, 95%CI 0.04-0.09) with comparable detection rates (3.96% vs 3.70%, p=0.052) but different proportions of various cytological abnormalities (p<0.001). The 2007-2009 Siriraj-LBC had a negative predictive value (NPV) for cervical intraepithelial neoplasia 2+ (CIN2+) of 97.6% and an overall positive predictive value (PPV) of 43.9%. The PPV for CIN2+ varied with types of abnormal cytology, from 13.7% to 93.8% in atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells cannot exclude HSIL (ASC-H), high-grade squamous intraepithelial lesion (HSIL), atypical glandular cells (AGC), to squamous cell carcinoma (SCC), respectively. The PPVs for CIN2+ in ASCUS and LSIL were comparable, but the PPV for CIN1 was higher for LSIL than for ASCUS (41.63% vs 16.32%). Conclusions: Siriraj-LBC has demonstrated a stable detection rate and NPV for CIN2+ of >95% since the first year of use. The comparable PPVs for CIN2+ of ASCUS and LSIL suggests that these two conditions may undergo similar management; other cytological abnormalities need immediate evaluation.

#Cervix #liquid-based cytology #Pap smear #squamous intraepithelial lesion

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